YAP1 - Wikipedia
YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis.
Hippo-YAP信号通路与肿瘤关系的研究进展 - 肿瘤研究与临床
Yes相关蛋白(Yes-associated protein, YAP)是经典Hippo信号通路的主要效应因子，被Wts磷酸化而失活。 近年的研究证明，YAP是一个癌基因，作为Hippo信号通路的下游信号分子，YAP具有促进细胞增殖、抑制细胞凋亡、导致细胞接触性抑制丧失及促进细胞恶性转化的作用 [ 1 ] 。
YAP - Hippo 信号转导通路的介导物 | Cell Signaling Technology
YAP（Yes 相关蛋白，YAP65）是一种转录共激活蛋白，可用作 Hippo 抑癌基因通路的主要效应子。 通过 YAP 进行的 Hippo 信号转导在某种程度上可调控干细胞和祖细胞的增殖活性，从而调控组织生长和器官大小。
YAP1 Gene - GeneCards | YAP1 Protein | YAP1 Antibody
2024年12月25日 · Complete information for YAP1 gene (Protein Coding), Yes1 Associated Transcriptional Regulator, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Yes-associated protein regulates endothelial cell contact …
2015年5月12日 · Hippo-Yes-associated protein (YAP) signalling has emerged as a key pathway that controls organ size and tissue growth by mediating cell contact inhibition. However, the role of YAP in EC has not...
The roles and regulation of Yes-associated protein 1 in stem cells
2022年9月23日 · Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo signaling pathway, and it is involved in tumorigenesis, tissue repair, growth, and development. In this review, the biological roles and the mechanisms of YAP1 in mediating stem cell fate decisions are discussed, including cell proliferation, differentiation, and apoptosis.
IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its ...
Yes-associated protein (YAP) is a major transcriptional co-activator of the Hippo pathway. The scaffold protein IQGAP1 interacts with more than 100 binding partners to integrate diverse signaling pathways. In this study, we report that IQGAP1 binds to YAP and modulates its activity. IQGAP1 and YAP co-immunoprecipitated from cells.
Hippo/yes-associated protein signaling functions as a …
2022年1月1日 · Evidence suggests that mechanical signals assist activated intracellular signal transduction pathways and the relative phenotypic adaptation to coordinate cell behavior and disease appropriately. The Hippo/yes-associated protein (YAP) signaling pathway is regulated in response to numerous mechanical stimuli.
Is activated Yes-Associated Protein (YAP) associated with renal …
3 天之前 · The Hippo signaling pathway, particularly through Yes Associated Protein (YAP), has been implicated in the fibrotic response. However, limited studies have examined YAP expression, along with its coactivator Transcriptional Enhanced Associate Domain (TEA Domain - TEAD) and downstream effector Connective Tissue Growth Factor (CTGF), in human ...
CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability …
6 天之前 · The aberrant upregulation of Yes-associated protein 1 (YAP1) in a variety of solid cancers contributes to tumor progression and poor clinical outcomes, rendering it an appealing therapeutic target.
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