CD8 + T cell differentiation and dysfunction in cancer - Nature
Jul 12, 2021 · Productive priming of tumour-specific CD8 + T cell and CD4 + T cell responses during early tumorigenesis would require sufficient cancer cell death and/or antigen release and uptake by...
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
Nov 1, 2023 · In cervical cancer patients, tumor cells promote the acquisition of a Tc2 cell phenotype by tumor-infiltrating CD8 T cells, which leads to increased production of IL-4 and decreased...
CD8+ T cell activation in cancer comprises an initial activation …
SUMMARY. Improvements in tumor immunotherapies depend on better understanding of the anti-tumor T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that activated CD8 + T cells in TDLNs shared functional, transcriptional, and epigenetic traits with TCF1 + stem-like cells in the tumor. The phenotype and TCR overlap suggested that these TDLN cells were precursors to ...
Cytotoxic CD8 + T cells in cancer and cancer immunotherapy
Sep 15, 2020 · Persistent exposure of CD8 + T cells to tumour neoantigens can induce the sustained expression of immune-checkpoint molecules, which characterises—and might drive—the dysfunctional state ...
CD8 + T cells in the cancer-immunity cycle - PubMed
Oct 10, 2023 · CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8<sup>+</sup> T cell effector function. Here, we review the current understanding of T cell function in cancer, focusing on key CD8<sup>+</sup> T cell subtypes and states.
CD8 + T cells in the cancer-immunity cycle - Cell Press
CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8 + T cell effector function. Here, we review the current understanding of T cell function in cancer, focusing on key CD8 + T cell subtypes and states. We discuss factors that influence CD8 + T cell differentiation and function in cancer ...
Focusing on CD8 + T-cell phenotypes: improving solid tumor …
Sep 28, 2024 · Here, we review the newly discovered methods to enhance the function of CD8 + T cells against solid tumors, focusing on optimizing T cell receptor (TCR) expression, improving antigen recognition by engineered T cells, enhancing signal transduction of the TCR-CD3 complex, inducing the homing of polyclonal functional T cells to tumors, reversing ...
CD8 + T cell differentiation and dysfunction in cancer - PubMed
Here we review CD8 + T cell differentiation to dysfunctional states during tumorigenesis. We highlight similarities and differences between T cell dysfunction and other hyporesponsive T cell states and discuss the spatio-temporal factors contributing …
Circadian tumor infiltration and function of CD8+ T cells dictate ...
Efficacy of CAR T cell therapy and immune checkpoint blockade in cancer can be improved by adjusting the time of treatment during the day due to rhythmic infiltration and function of T cells regulated by the circadian clock in T cells and endothelial cells in the tumor microenvironment.
CD8 + cytotoxic T lymphocytes in cancer immunotherapy: A review - PubMed
CD8 + cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with all favor adaptive immune-resistance …
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