Oncosis: an important non-apoptotic mode of cell death
In this review we have described the many characteristics of oncosis from a morphological and biochemical standpoint, and we briefly examine the application of oncosis in disease processes.
Apoptosis, oncosis, and necrosis. An overview of cell death
The term oncosis (derived from ónkos, meaning swelling) was proposed in 1910 by von Reckling-hausen precisely to mean cell death with swelling. Oncosis leads to necrosis with karyolysis and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Oncosis and apoptosis induction by activation of an ... - Nature
Jul 31, 2017 · Pharmacological activation of TRPV4 produced pronounced cell death through two mechanisms: apoptosis and oncosis in MDA-MB-468 cells.
The molecular machinery of regulated cell death | Cell Research
Apr 4, 2019 · Kerr et al. defined apoptosis as a form of programmed cell death (PCD) with morphological changes that differ from necrosis. 1 Apoptosis and its dysregulation underlies various pathological and...
Oncosis - Apoptosis and Beyond - Wiley Online Library
Sep 12, 2018 · This manner of cell death is morphologically, biochemically and genetically distinct from apoptosis. Briefly, oncosis displays formation of blisters (often one, but rarely two) which lack of organelles, have patchy chromatin condensation, and exhibit increase in vacuolization.
Unravelling oncosis: morphological and molecular insights into a …
Aug 29, 2024 · In this review, we provide a detailed examination of the morphological and molecular features of oncosis and discuss various natural or small molecule compounds that can induce this type of cell death.
Frontiers | Unravelling oncosis: morphological and molecular …
Aug 28, 2024 · Recent research suggests that oncosis can impact conditions such as chemotherapeutic cardiotoxicity, myocardial ischemic injury, stroke, and cancer, mediated by specific oncosis-related proteins. In this review, we provide a detailed examination of the morphological and molecular features of oncosis and discuss various natural or small molecule ...
Oncosis - SpringerLink
Jan 1, 2011 · At the biochemical level, oncosis is a form of cell death induced by energy depletion, which produces dramatic reductions in mitochondrial respiration and ATP synthesis (Majno and Joris 1995). Diverse data suggest a central role …
Lysoptosis is an evolutionarily conserved cell death pathway
Jan 12, 2022 · We designated this cell death routine, lysoptosis, to distinguish it from other pathways employing LMP. In this study, mouse and human epithelial cells lacking srp-6 homologues, mSerpinb3a and ...
Modes of Myocardial Cell Injury and Cell Death in Ischemic …
Oct 6, 1998 · Necrosis, precisely defined, refers to the sum of degradative changes that follow any type of cell death. Apoptosis is characterized by cell death with cell shrinkage and fragmentation. Majno and Joris have applied the term “oncosis” to the contrasting pattern of cell death with cell swelling.
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