Oligodendrocytes and Microglia: Key Players in Myelin …
Oligodendrocytes, the myelin-making cells of the CNS, regulate the complex process of myelination under physiological and pathological conditions, significantly aided by other glial cell types such as microglia, the brain-resident, macrophage-like innate immune cells.
Microglial–oligodendrocyte interactions in myelination and …
2022年10月5日 · Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is altered by traumatic brain injury (TBI) and its impact on axonal myelination and neurological function impairment remain poorly understood.
Mertk-expressing microglia influence oligodendrogenesis and …
2023年11月6日 · Here we demonstrate an unexpected role for Mertk-expressing microglia in both oligodendrogenesis and myelination. The selective depletion of Mertk from microglia resulted in reduced oligodendrocyte production in early development and …
Microglial neuropilin-1 promotes oligodendrocyte expansion …
2021年4月15日 · Nrp1 loss from activated microglia that appeared in the demyelinated lesion led to a severe decrease in OPC proliferation followed by decreased OL regeneration and protracted remyelination.
Targeting microglia–oligodendrocyte crosstalk in …
2022年9月1日 · Microglia-oligodendroglia crosstalk is important in both health and disease. Predicted ligand-receptor interactions are dysregulated in MS and MDD. Ligand-receptor interactions between microglia and oligodendroglia are druggable.
Differential roles of astrocyte and microglia in supporting ...
Oligodendrocyte (OL) development relies on many extracellular cues, most of which are secreted cytokines from neighboring neural cells. Although it is generally accepted that both astrocytes and microglia are beneficial for OL development, there is a lack of understanding regarding whether astrocytes and microglia play similar or distinct roles.
Human iPSC-derived microglial cells protect neurons from ...
2025年1月9日 · For co-culturing microglia with ABO, two ways were used: (1) To seed microglia to a whole ABO, 0.02 million microglia were resuspended in brain organoid medium and then gently added to the ABO in ...
小胶质细胞 - 维基百科，自由的百科全书
小胶质细胞能通过细胞表面存在的一种特殊 钾离子通道 感知到 细胞外 钾离子 浓度的微小变化，进而使其得以对中枢神经系统的潜在微小病变及时做出反应，以防止这样的微小病变扩大为足以威胁机体生命的疾病 [6][7]。 尽管存在一些争议，但目前学界一般认为小胶质细胞发育起源于 中胚层 间充质 系细胞，后迁入 中枢神经系统，是一种适应了中枢神经系统中特殊微环境的 巨噬细胞，表面分子大都与 骨髓源性巨噬细胞 相同。 小胶质细胞的形态变化很大，能与中枢神经系统中的神 …
Regulation of myelination by microglia | Science Advances
2021年12月10日 · Microglia are mechanistically poised to sense and respond to the changing conditions in the developing brain through a plethora of signaling pathways and phagocytic activity, yet we are only beginning to understand the multifaceted functions that microglia have during early myelination events.
Oligodendrocytes and Microglia: Key Players in Myelin
2021年7月20日 · Oligodendrocytes, the myelin-making cells of the CNS, regulate the complex process of myelination under physiological and pathological conditions, significantly aided by other glial cell types such as microglia, the brain-resident, macrophage-like innate immune cells. In this review, we summarize ho …
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