Homologous recombination in DNA repair and DNA damage …
2008年1月1日 · Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In addition,...
Homologous recombination - Wikipedia
Homologous recombination is widely used by cells to accurately repair harmful DNA breaks that occur on both strands of DNA, known as double-strand breaks (DSB), in a process called homologous recombinational repair (HRR).
Homologous recombination in DNA repair and DNA damage …
Pathways of recombination in DSB repair. Homologous recombination can be conceptually divided into three stages: presynapsis, synapsis, and postsynapsis. During presynapsis, DSB ends are recognized and processed to a 3′-OH ending single-stranded tail (steps 1–2).
Repair of Strand Breaks by Homologous Recombination - PMC
Homologous recombination is one major pathway to repair such breaks. In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals.
Homologous Recombination Repair | SpringerLink
2017年1月1日 · Homologous recombination repair is a DNA repair process that includes the invasion of an undamaged DNA molecule by a damaged molecule of identical or very similar sequence. Resynthesis of the damaged region is accomplished using the undamaged molecule as …
Homologous recombination and the repair of DNA double …
Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix. Here, we discuss the DNA transactions and enzymatic activities ...
Homologous Recombination - an overview | ScienceDirect Topics
Homologous recombination is one of the major pathways for the repair of double-strand breaks (DSBs). As the term implies, it is mediated through sequences which exhibit considerable homology (generally >200 bp) that presumably serves to stabilize chromosomal mispairing.
ATRX and RECQ5 define distinct homologous recombination subpathways - PNAS
2021年1月11日 · Homologous recombination (HR) is an important DNA double-strand break (DSB) repair pathway that copies sequence information lost at the break site from an undamaged homologous template. This involves the formation of a recombination structure that is processed to restore the original sequence but also harbors the potential for crossover (CO ...
Pathway choice in DNA double strand break repair: observations …
2012年11月27日 · Proper repair of DNA double strand breaks (DSBs) is vital for the preservation of genomic integrity. There are two main pathways that repair DSBs, Homologous recombination (HR) and Non-homologous end-joining (NHEJ).
Homologous recombination and the repair of DNA double …
2018年7月6日 · Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the context of the repair of DNA double-strand breaks in somatic cells. This includes homology search, DNA strand invasion, repair DNA synthesis, and restoration of intact chromosomes.