High-throughput screening - Wikipedia
High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science [1] and chemistry. [2][3] Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly cond...
High-Throughput Screening (HTS) Technology | SpringerLink
2022年1月1日 · HTS is a translational research technology used for identifying effectors (compounds, peptides, and biologics) that modulate target-specific biochemical or cell-based assays. In the context of small molecule drug discovery, HTS involves performing assays in the presence of large collections of compounds.
High-Throughput Screening: today’s biochemical and cell-based ...
2020年10月1日 · High-throughput screening (HTS) provides starting chemical matter in the adventure of developing a new drug. In this review, we survey several HTS methods used today for hit identification, organized in two main flavors: biochemical and cell-based assays.
High-Throughput Screening Technology in Industrial …
2020年8月1日 · We discuss the most significant factors that can improve HTS efficiency, including the construction of screening libraries with high diversity and the use of new detection methods to expand the search range and highlight target compounds. We also summarize applications of HTS for enhancing the performance of industrial microorganisms.
High-Throughput Screening Technology in Industrial Biotechnology
We discuss the most significant factors that can improve HTS efficiency, including the construction of screening libraries with high diversity and the use of new detection methods to expand the search range and highlight target compounds. We also summarize applications of HTS for enhancing the performance of industrial microorganisms.
Advances in ultrahigh-throughput screening technologies for …
2023年9月1日 · Numerous ultrahigh-throughput screening toolkits have been developed for the efficient screening of various protein libraries, such as intracellular enzymes, periplasmic proteins, binding peptides, secreted proteins, and membrane proteins, to achieve outstanding performance.
High-throughput screening (HTS) is a well-established process in lead discovery for pharma and biotech companies and is now also being set up for basic and applied research in academia and some research hospitals.
High-Throughput Screening: Advances, Applications and …
2024年5月24日 · High-throughput screening (HTS) is a drug discovery approach that involves screening vast libraries of small molecules to identify “hits” with therapeutic potential. As a result of exciting past scientific breakthroughs, HTS approaches have been miniaturized, standardized and …
High-Throughput Screening: Evolution of Technology and Methods
2010年3月15日 · Over the last 20 years high-throughput screening (HTS) has become a successful, reliable component of the drug discovery process. This article focuses on the variety of screening plate formats and the implications of their usage on …
various high-throughput screening (HTS) strategies have been established for improving the performance of industrial microorganisms. We discuss the most significant factors that can improve HTS efficiency, including the construction of screening libraries with high diversity and the use of new detection methods