Glutamic acid - Wikipedia
Glutamic acid (symbol Glu or E; [4] the anionic form is known as glutamate) is an α- amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can synthesize enough for its use.
Glutamate - Neuroscience - NCBI Bookshelf
Glutamate is a nonessential amino acid that does not cross the blood-brain barrier and must be synthesized in neurons from local precursors. The most prevalent glutamate precursor in synaptic terminals is glutamine.
Biochemistry, Glutamate - StatPearls - NCBI Bookshelf
2022年12月19日 · Glutamate is the principal excitatory neurotransmitter of the central nervous system and the most abundant neurotransmitter in the brain. It is stored within vesicles in axon terminals and released via exocytosis upon the influx of calcium cations.
Glutamate (neurotransmitter) - Wikipedia
Glutamate is synthesized in the central nervous system from glutamine as part of the glutamate–glutamine cycle by the enzyme glutaminase. This can occur in the presynaptic neuron or in neighboring glial cells.
The Many Roles of Glutamate in Metabolism - PMC
Glutamate is made from the citric acid cycle intermediate 2-oxoglutarate (2-OG) by reductive amination with either ammonium or glutamine as the nitrogen source. Glutamate biosynthesis is not only important for production of glutamate; it is also the major route for the assimilation of …
Glutamate and GABA synthesis, release, transport and ...
2012年9月1日 · This brief review is focused entirely on the metabolic aspects of glutamate and GABA synthesis and neurotransmission. It describes in limited detail the synthesis, release, reuptake, metabolism, cellular compartmentation and pharmacology of the glutamatergic and GABAergic synapse.
Neurotransmitter Synthesis and Storage – Foundations of ...
Glutamate is an amino acid transmitter and is the primary excitatory neurotransmitter in the brain. In the presynaptic terminal, glutamine is converted into glutamate via the enzyme glutaminase, which is the rate-limiting step in the synthesis pathway. Glutamate is packaged into vesicles for storage via the vesicular glutamate transporter.