Cytokine - Wikipedia
Cytokines typically activate second messenger systems, like JAK-STAT pathways, as illustrated on the left side of the diagram. Conversely, hormones typically activate different signaling pathways, like G protein-coupled receptors, seen at the top of the figure.
The JAK-STAT pathway: from structural biology to cytokine …
2024年8月21日 · The JAK-STAT pathway cytokines and their receptors. a Exemplary structures of typical cytokines, colored as a spectrum from the N- (blue) to the C-terminus (red).
Pathways for Cytokine Secretion | Physiology
2010年8月1日 · These findings begin to elucidate pathways and mechanisms that underpin cytokine release in all cells. In this article, we review the highlights of some of these novel discoveries. The secretion of cytokines and chemokines from cells is a fundamental response to injury and infection in the body.
Cytokine Storm | New England Journal of Medicine
2020年12月2日 · Cytokine storm is an umbrella term encompassing several disorders of immune dysregulation characterized by constitutional symptoms, systemic inflammation, and multiorgan dysfunction that can lead...
Targeting cytokine and chemokine signaling pathways for cancer …
2024年7月22日 · Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer.
Systematic investigation of cytokine signaling activity at the …
2021年9月30日 · This atlas of transcriptional patterns induced by cytokines enabled the reliable prediction of signaling activities in distinct cell populations in infectious diseases, chronic inflammation and...
Navigating the Cytokine Seas: Targeting Cytokine Signaling Pathways …
2024年1月13日 · Targeting cytokine signaling pathways provides a strategic approach to modulating cytokine-mediated effects and enhancing therapeutic efficacy. This review article provides an overview of the significance of cytokines in cancer therapy, highlighting their multifaceted roles in modulating immune responses, tumor growth, and therapeutic ...
Role of SARS-CoV-2-induced cytokine storm in multi-organ …
Inflammatory pathways, including JAK/STAT signaling pathway , IFN cell signaling pathway , NF-κB pathway , TLR pathway, etc. are activated in COVID-19-associated cytokine storm. Moreover, levels of IL-1, IL-6, TNF, IFN-γ, and IFN-γ-induced protein 10 (IP-10) are elevated in patients with COVID-19 and are thought to have leading roles in ...
Cytokine receptor signaling pathways - Journal of Allergy and …
Cytokines use multiple signaling pathways. This review will focus on signaling by type I cytokines and in particular on signaling by the IL-2 family of cytokines, as an illustrative example. The major signaling pathway that will be discussed is the Jak-STAT pathway, although other pathways will also be reviewed.
The signal pathways and treatment of cytokine storm in COVID …
2021年7月7日 · We also discuss the induction, function, downstream signaling, and existing and potential interventions for targeting these cytokines or related signal pathways.
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