Corticosteroid-Binding Globulin: A Review of Basic and Clinical ...
Corticosteroid-binding globulin (CBG, transcortin) is the primary cortisol binding protein. It is a non-inhibitory serine protease inhibitor, capable of conformational change from a high cortisol-binding affinity form to a low affinity form upon cleavage of …
Transcortin - Wikipedia
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6, is a protein produced in the liver in animals. In humans it is encoded by the SERPINA6 gene . It is an alpha-globulin .
Corticosteroid-Binding Globulin: Structure-Function Implications …
Corticosteroid-binding globulin (CBG) transports glucocorticoids and progesterone in the blood and thereby modulates the tissue availability of these hormones. As a member of the serine protease inhibitor (SERPIN) family, CBG displays a reactive center loop …
Corticosteroid-binding globulin: Modulating mechanisms of ...
2015年10月1日 · Corticosteroid-binding globulin (CBG) is the principal transport protein of glucocorticoids. Approximately 80–90% of serum cortisol binds to CBG with high affinity and only about 5% of cortisol remain unbound and is considered biologically active. CBG seems to modulate and influence the bioavailability of cortisol to local tissues.
Plasma steroid-binding proteins: primary gatekeepers of steroid …
Biologically active steroids are transported in the blood by albumin, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG). These plasma proteins also regulate the non-protein-bound or ‘free’ fractions of circulating ...
Transcortin - an overview | ScienceDirect Topics
The main transport protein for glucocorticoids in the vascular system is termed corticosteroid-binding globulin, also known as transcortin, an alpha-globulin produced and secreted by the liver. Additionally, a small percentage of circulating glucocorticoids are bound to albumin.
Corticosteroid-Binding Globulin is expressed in the adrenal …
2019年9月30日 · Corticosteroid-binding globulin (CBG) is synthesized by the liver and secreted into the bloodstream where binds to glucocorticoids. Thus CBG has the role of glucocorticoid transport and free ...
Corticosteroid-Binding Globulin is a biomarker of inflammation …
Plasma corticosteroid-binding globulin (CBG) plays a critical role in regulating glucocorticoid bioavailability and is an acute phase “negative” protein during inflammation. In an adjuvant-induced arthritis model, plasma CBG levels decrease in rats that develop severe inflammation, and we have now determined when and how these reductions in ...
New Roles for Corticosteroid Binding Globulin and Opposite …
2016年1月7日 · Corticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role.
Corticosteroid-binding Globulin, a Structural Basis for Steroid ...
2007年10月5日 · Corticosteroid-binding globulin (CBG) is a serine proteinase inhibitor (serpin) family member that transports glucocorticoids in blood and regulates their access to target cells.
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