谷氨酸棒状杆菌 - 百度百科
谷氨酸棒状杆菌（ Corynebacterium glutamicum ）是近四十年来全球用以 氨基酸 发酵工业的主要生产菌，早在1957年由Kinoshita首次描述其为谷氨酸产生菌。 谷氨酸棒状杆菌在分类上属于 革兰氏阳性 真细菌下的放线纲 棒状杆菌属 。
Corynebacterium glutamicum - Wikipedia
Corynebacterium glutamicum is a Gram-positive, rod-shaped bacterium that is used industrially for large-scale production of amino acids, [3] [4] especially glutamic acid and lysine. [5] While originally identified in a screen for organisms secreting L-glutamate , mutants of C. glutamicum have also been identified that produce various other ...
Corynebacterium glutamicum - an overview | ScienceDirect Topics
Corynebacterium glutamicum is a non-pathogenic and non-sporulating bacteria classified as GRAS. It is widely used for large-scale production of various organic compounds, such as organic acids [262,263], alcohols [264–266] and pyrazine [267–269], and has a special significance in the industrial production of amino acids [270–274].
理性代谢工程改造促进谷氨酸棒杆菌高效合成L-谷氨酸
以谷氨酸高产菌谷氨酸棒杆菌 (Corynebacterium glutamicum) G01为出发菌株，首先通过敲除主要副产物丙氨酸合成相关基因-丙氨酸氨基转移酶编码基因 (alaT)，降低了发酵副产物丙氨酸含量。 其次，α-酮戊二酸节点碳流量对谷氨酸合成起重要作用，因此，采用核糖体结合位点 (ribosome-binding site, RBS)序列优化降低了α-酮戊二酸脱氢酶的活性，强化了谷氨酸合成代谢流。 同时通过筛选不同来源的谷氨酸脱氢酶，加强了α-酮戊二酸内源转化为谷氨酸的能力。 接着，对谷氨酸 …
谷氨酸棒杆菌的代谢工程使能技术研究进展
文中综述了近期针对谷氨酸棒杆菌开发的代谢工程使能技术，着重介绍了基于CRISPR的基因组编辑、基因表达调控、适应性进化和生物传感器等技术的开发和应用。 1. Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology, Tianjin 300308, China; 2. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
Metabolic engineering of Corynebacterium glutamicum
2024年12月1日 · In recent years, metabolic engineering of Corynebacterium glutamicum has emerged as a promising approach for enhancing the production of organic acids. C. glutamicum is a Gram-positive bacterium, known for its several notable characteristics, including facultative anaerobiosis, rapid growth, and the absence of endotoxins (Minh, 2024).
Metabolic engineering of Corynebacterium glutamicum for …
2021年12月24日 · Corynebacterium glutamicum (C. glutamicum) possesses clear genetic background and mature gene manipulation toolbox, and has been utilized as industrial host for producing BCAAs. Acetohydroxy acid synthase (AHAS) is a crucial enzyme in the BCAAs biosynthetic pathway of C. glutamicum, but feedback inhibition is a disadvantage.
Metabolic Engineering of Corynebacterium glutamicum for …
2021年9月23日 · A promising alternative is the microbial production of nucleotide sugars from cheap substrates. In this study, we aimed to engineer the non-pathogenic, Gram-positive soil bacterium Corynebacterium glutamicum as a host for UDP-GlcNAc production.
Review of the Proteomics and Metabolic Properties of
2024年8月15日 · Corynebacterium glutamicum (C. glutamicum) has become industrially important in producing glutamic acid and lysine since its discovery and has been the subject of proteomics and central carbon metabolism studies. The proteome changes depending on environmental conditions, nutrient availability, and stressors.
The pivotal role of Corynebacterium glutamicum in l-Glutamic …
2023年1月1日 · Corynebacterium glutamicum (previously known as Micrococcus glutamicus) is a Gram + ve, a non-motile, non-sporulating, non-pathogenic, pleomorphic rod-shaped bacterium with a dimension of 0.7-1X1-3 μm, with a G + C content of 53–55%, forming yellow colony which has immense industrial importance, especially from the white biotechnological ...