For several decades, tree shrew, the closest relative of primates, has attracted increasing attention in modeling human diseases and therapeutic responses. It has been used as a viable animal model alternative to rodents and primates in biomedical researches such as hepatitis virus infection, myopia, social stress and depression.
For several decades, tree shrew, the closest relative of primates, has attracted increasing attention in modeling human diseases and therapeutic responses. It has been used as a viable animal model alternative to rodents and primates in biomedical researches such as hepatitis virus infection, myopia, social stress and depression.
present a publicly available annotated genome sequence for the Chinese tree shrew. Phy-logenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique
features of AD in aged tree shrews. We found abnormal changes, including impaired cognitive performance, and increased levels of Aβ accumulation, phosphorylated tau, synaptic degeneration, neuronal loss, and gliosis in aged animals compared to adult tree shrews. Our results provide further evidence to support the Chinese tree shrew as being
The comprehensively updates of the tree shrew genome database were aimed to provide up-to-date and user-friendly accesses to tree shrew genomic and transcriptomic data.
reliable tree shrew genome annotation (KIZ version 3: TS_3.0). Based on this comprehensive annotation, we further explored the spatial expression and alternative splicing patterns of the tree shrew transcripts and characterized the orthologous …
RNA-seq reveal liver changes in the early stage of diabetes in tree shrew, control: Liver (diabetes) KIZ: SRX1009946: RNA-seq reveal liver changes in the early stage of diabetes in tree shrew: Hepatocyte: NIBS: SRX125163: Yan H et al, 2012: Hepatocyte RNA-seq: DGC-enriched Thy1- cells 1: KIZ: TSDB2017R01:
Study of tree shrew biology and models: A booming and prosperous field for biomedical research Yong-Gang Yao1,2,3,4,*, Li Lu1,2,3,4, Rong-Jun Ni5,6, Rui Bi1,2,3,4,§, Ceshi Chen1, Jia-Qi Chen2, Eberhard Fuchs7,
The Chinese tree shrew (Tupaia belangeri chinese) has been increasingly used as an alternative experimental animal to primates in studying viral infectious diseases. Hitherto, the tree shrew GBP family has not been characterized.