It was sold under a variety of brand names including Reductil, Meridia, Siredia, and Sibutrex. In 2002, studies looked into reports of sudden death, heart failure, renal failure and gastrointestinal problems.
Sibutramine dosing information. Usual Adult Dose for Obesity: Sibutramine was voluntarily withdrawn from the US market by the manufacturer in October, 2010 due to clinical trial data indicating an increased risk of heart attack and stroke.
Reductil is a medication used to help individuals who are obese – i.e. with a body mass index (BMI) ≥ 30 – to lose weight. Before a doctor will prescribe Reductil to you, you must have previously tried to lose weight by modifying your diet and …
Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States.
Sibutramine (Reductil, Abbott-Knoll, 10 mg and 15 mg) is a new appetite regulator recommended in the treatment of obesity. It is a noradrenaline and 5-hydroxytryptamine reuptake inhibitor which exerts its effects in vivo predominantly via its secondary and primary amine metabolites.
Adults: The starting dose is one Reductil 10 mg capsule (equivalent to 1 O mg of s1butramine hydrochloride monohydrate) once daily. Patients who respond unsatisfactorily to Reductil 10 mg (I.e. less than 2 kg weight loss in 4 weeks) may be switched to 1 capsule of Reductil 15 mg· (equivalent to 15 mg
Absorption Sibutramine is rapidly absorbed from the GI tract (T. max . of 1.2 hours) following oral administration and undergoes extensive first-pass metabolism in the liver (oral clearance of 1750 L/h and half-life of 1.1 h) to form the pharmacologically active mono- and di