Pseudouridine Formation, the Most Common Transglycosylation …
Pseudouridine (Ψ) synthases are the enzymes responsible for the most abundant and phylogenetically conserved posttranscriptional modification of cellular RNAs. These enzymes catalyze an isomerization reaction of specific uridine residues within an RNA chain.
The Critical Contribution of Pseudouridine to mRNA COVID-19 …
Here we highlight the features of N1-methyl-pseudouridine and its contributions to mRNA vaccines. Keywords: COVID-19, SARS-CoV-2, mRNA, vaccines, RNA modification, pseudouridine, N1-methyl-pseudouridine, lipid nanoparticles. Introduction. When the COVID-19 pandemic struck in early 2020, there was an urgent need to generate COVID-19 vaccines.
Modified uridines are the key to a successful message
2021年9月27日 · Katalin Karikó describes the discovery that replacing uridine with pseudouridine renders RNA non-immunogenic. This paved the way for developing mRNA for protein replacement therapy and ...
Regulation and Function of RNA Pseudouridylation in Human …
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of non-coding RNA in human cells. The known molecular functions of pseudouridine, which include stabilizing RNA ...
Pseudouridine in a new era of RNA modifications - PMC
Pseudouridine (Ψ) was among the first post-transcriptional modifications discovered and is overall one of the most abundant 1. It is present in a wide range of cellular RNAs and is highly conserved across species.
Pseudouridines in RNAs: switching atoms means shifting paradigms
2021年9月13日 · Pseudouridine (Ψ) is one of the most abundant post‐transcriptional RNA base modifications and has been detected at individual positions in tRNAs, rRNAs, mRNAs, and snRNAs, which are referred to as Ψ‐sites.
Regulation and Function of RNA Pseudouridylation in Human Cells
2020年11月23日 · The known molecular functions of pseudouridine, which include stabilizing RNA conformations and destabilizing interactions with varied RNA-binding proteins, suggest that RNA pseudouridylation could have widespread effects on RNA metabolism and gene expression.
Transcriptome-wide dynamics of RNA pseudouridylation
2015年8月19日 · Pseudouridine is the most abundant internal post-transcriptional modification of spliceosomal small nuclear RNAs and ribosomal RNAs.
Transcriptome-wide dynamics of RNA pseudouridylation
Pseudouridine (Ψ) nucleosides are introduced into pre-mRNAs at coding and non-coding exons and presumably also at introns.
Pseudouridine: still mysterious, but never a fake (uridine)!
Pseudouridine (Ψ) is the most abundant of >150 nucleoside modifications in RNA. Although Ψ was discovered as the first modified nucleoside more than half a century ago, neither the enzymatic mechanism of its formation, nor the function of this modification are fully elucidated.
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