Tumor Suppressor p53: Biology, Signaling Pathways, and …
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered.
p53 - Wikipedia
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. [ 5 ] .
The TP53 Gene and Its Role in Cancer - Verywell Health
2023年10月25日 · What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of …
p53 signaling in cancer progression and therapy | Cancer Cell ...
2021年12月24日 · Several studies have shown that transfection of cancer cells with wild-type p53 expressing plasmids can induce apoptosis and/or growth arrest, implying that a gene therapy method for cancer treatment could be based on restoring normal p53 expression and function.
Mutant p53 in cancer: from molecular mechanism to therapeutic …
2022年11月18日 · Emerging evidence suggests that mutp53 is highly associated with advanced malignancies and poor prognosis, which makes it a target for development of novel cancer therapies. Herein, we...
Drugging p53 in cancer: one protein, many targets - Nature
2022年10月10日 · This paper reports a bispecific antibody, highly specific to the p53(R175H) mutation, which activates T cells to kill cancer cells presenting a p53(R175H)-derived neoantigen in vitro and in...
Targeting p53 pathways: mechanisms, structures and advances in …
2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53mutations impact tumor progression.
Role of p53 in Cell Death and Human Cancers - PMC - PubMed …
Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53. Indeed, mutant p53 has an oncogenic potential.
Understanding the complexity of p53 in a new era of tumor …
2024年5月9日 · p53 plays a central role in suppressing tumorigenesis. In this issue, Liu et al. review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that largely expand the scope of …
The p53 tumor suppressor protein - Genes and Disease - NCBI Bookshelf
The amount of information that exists on all aspects of p53 normal function and mutant expression in human cancers is now vast, reflecting its key role in the pathogenesis of human cancers. It is clear that p53 is just one component of a network of events that culminate in tumor formation.