Nrf2 suppresses macrophage inflammatory response by blocking ...
2016年5月23日 · Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation...
Nrf2 suppresses macrophage inflammatory response by …
2016年5月23日 · Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment.
Nrf2 activation reprograms macrophage intermediary …
2022年2月18日 · To understand how Nrf2 regulates macrophage biology, we used high-resolution mass spectrometry (MS) to characterize the proteomes of bone marrow-derived macrophages (BMDMs) differentiated ex vivo from bone marrow cells isolated from, respectively, wild-type (WT), Keap1-knockdown (Keap1-KD, expressing ∼70% lower levels of Keap1 compared to WT ...
Macrophage achieves self-protection against oxidative stress …
2019年2月14日 · We further show that Mst1/2 function as critical ROS sensors and attenuators through stabilizing nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also known as NFE2L2), a major antioxidant...
Nrf2 signaling pathway: Pivotal roles in inflammation
2017年2月1日 · A very recent investigation based on chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR results in mouse macrophages revealed that Nrf2 binds to the promoter regions of pro-inflammatory cytokines such as IL-6 and IL-1β and inhibits RNA Pol II recruitment.
Nrf2 Signaling in Macrophages - PMC - National Center for …
Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to result from its upregulation of cellular antioxidant defenses via the antioxidant response element-driven transcription.
Nrf2-mediated anti-inflammatory polarization of macrophages as ...
2022年8月12日 · In this review, we reviewed the role of macrophage phenotypes in driving and relieving inflammation due to OA and summarized how NF-κB, Nrf2, and their crosstalk shape macrophage polarization. As Nrf2 signaling is believed to impact cellular metabolism, studying the effects of activators of Nrf2 on macrophage metabolism and phenotype related ...
Macrophage nuclear factor erythroid 2‐related factor 2 deficiency ...
2021年12月10日 · Nrf2 expression in macrophages is increased and negatively correlates with IR stress‐induced liver injury in patients. To explore the role of macrophage Nrf2 in the pathogenesis of hepatic IRI, we first examined Nrf2 expression in macrophages of liver specimens from 30 patients undergoing OLT.
Macrophage Nrf2, an anti-inflammatory signal in hepatic …
2023年1月5日 · Nrf2 is generally considered a redox signaling controller and drives protective signals as an antioxidant gene in multiple organs and diseases. Rao et al. discovered that independent of its...
Nrf2-mediated anti-inflammatory polarization of macrophages as …
2022年8月12日 · The transition of synovial macrophages between pro-inflammatory and anti-inflammatory phenotypes can play a key role in building the intra-articular microenvironment. The pro-inflammatory cascade induced by TNF-α, IL-1β, and IL-6 is closely related to M1 macrophages, resulting in the production of pro-chondrolytic mediators.
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