miRNA Mimics & Inhibitors | Thermo Fisher Scientific - US
mirVana miRNA mimics are chemically modified double-stranded RNA molecules designed to mimic endogenous microRNAs (miRNAs), resulting in down-regulation of target mRNA translation due to mRNA sequestration or degradation.
miScript miRNA Mimics - QIAGEN
miScript miRNA Mimics are chemically synthesized, double-stranded RNAs which mimic mature endogenous miRNAs after transfection into cells. miScript miRNA Mimics are available at cell-culture grade (>90% purity) or animal grade (HPLC purified; for in vivo applications).
The guideline of the design and validation of MiRNA mimics
Unlike endogenous miRNAs, miR-Mimics act in a gene-specific fashion. The miR-Mimic approach belongs to the "miRNA-targeting" and "miRNA-gain-of-function" strategy and is primarily used as an exogenous tool to study gene function by targeting mRNA through miRNA-like actions in mammalian cells.
mirVanaTM miRNA mimics are small, chemically modified, double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of ∙ miRNA activity. mirVanaTM miRNA Mimics exhibit maximum and consistent effect in vitro at low concentration.
New Tools for MicroRNA Functional Analysis—mirVana miRNA Mimics …
mirVana™ miRNA mimics are small, chemically modified double-stranded RNA molecules that are designed to mimic endogenous mature miRNAs, resulting in artificial down-regulation of target mRNA translation and accompanied, in some cases, by reduction in transcript levels.
MicroRNA therapeutics: towards a new era for the …
2017年2月17日 · Several miRNA-targeted therapeutics have reached clinical development, including a mimic of the tumour suppressor miRNA miR-34, which reached phase I clinical trials for treating cancer,...
miRNA Mimic & Inhibitor Libraries - Thermo Fisher Scientific
This comprehensive overview of miRNA mimic and inhibitor screening provides a detailed case study of the identification of miRNAs that control infection by the bacterial pathogen Samonella. It includes methodologies that are readily adaptable for screens to address a wide variety of biological questions.
miRNA mimics simulate the natural functions of endogenous miRNAs and are primarily used in gain-of-function studies, enabling the assessment of the biological consequences of increasing miRNA activity.
Next-generation poly-L-histidine formulations for miRNA mimic …
2023年6月8日 · miRNA mimics are a promising technology with therapeutic potential to treat numerous diseases caused by depleted levels of specific miRNAs. miRNA mimics are synthetic double-stranded nucleic acids that mimic the activity of endogenous miRNAs through the activation of the RISC via the Argonaute 2 protein. 12 The synthetic nucleic acid design ...
miRIDIAN microRNA Mimic - Horizon Discovery
miRIDIAN microRNA Mimics are double-stranded RNA oligonucleotides designed to mimic the function of endogenous, mature microRNAs. miRIDIAN Mimics are chemically enhanced with the ON-TARGET modification pattern to preferrentially …
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