LGALS3BP in Microglia Promotes Retinal Angiogenesis Through
2022年7月8日 · The lectin galactoside-binding soluble 3 binding protein (LGALS3BP), a member of the scavenger receptor cysteine-rich (SRCR) domain protein family, is involved in tumor neovascularization, and we therefore hypothesized that LGALS3BP plays an active role in microglia-induced angiogenesis.
Microglial signatures and their role in health and disease
The upregulated genes in Aβ-plaque-associated microglia, also known as disease-associated microglia (‘DAM microglia’), included Axl, Apoe, Clec7a, Itgax, Lgals3 and Cst7, which are now known to be part of a common neurodegenerative 52 and disease-associated signature that has been observed by several groups 26,111,141,142 (see below; FIG. 2a).
Galectins as regulators of cell survival in the leukemia niche
2019年1月1日 · Galectins are a family of beta-galactoside binding proteins that are critical components in the tumor microenvironment. Galectin 1 (LGALS1) and Galectin 3 (LGALS3) as regulators of RAS signaling intracellularly and as inhibitors of immune cells extracellularly are perhaps the best studied members for their role in leukemia biology.
Microglial Galectin3 enhances endothelial metabolism and …
2023年6月28日 · Here, we report that galectin-3 (Gal3) released by activated microglia functions as a communicator between microglia and endothelia and competitively binds to Jag1, thus inhibiting the Notch...
Genetic targeting or pharmacological inhibition of galectin-3 …
2022年9月17日 · To determine if galectin-3 modulates microglia activity during light-induced retinal degeneration, we used galectin-3 (Lgals-3) KO mice. Our data demonstrate that microglia from Lgals -3 KO mice showed no morphological differences or other phenotypic abnormalities compared to WT littermates but much less reactivity.
Galectin-3 alleviates demyelination by modulating microglial anti ...
2024年11月1日 · Microglia, especially anti-inflammatory phenotype microglia are critical for remyelination. Galectin-3 (Gal-3), which is known to modulate microglia activation, is correlated with myelination. In this study, we aimed to elucidate the roles of Gal-3 during myelin formation and explore the efficiency and mechanism of rGal-3 administration in ...
Galectin-3, a rising star in modulating microglia activation under ...
2022年7月20日 · Galectin-3 (Gal-3) is a pleiotropic protein that binds to β-galactoside residues present in glycoproteins. Gal-3 is mainly expressed and released in the damaged brain by reactive...
Zebrafish Galectin 3 binding protein is the target antigen of the ...
The 4C4 monoclonal antibody recognizes Lgals3bpb, a predicted highly glycosylated protein whose function in the microglial lineage is currently unknown. Identification of Lgals3bpb as a new pan-microglia marker will be fundamental in forthcoming studies using the zebrafish model.
Galectin-3: a key player in microglia-mediated …
2021年4月27日 · One of the key molecules involved in microglial activation is galectin-3 (Gal-3). In recent years, extensive studies have dissected the mechanisms by which Gal-3 modulates microglial activation, impacting Aβ deposition, in both animal models and human studies.
Modulation of Neuro-Inflammatory Signals in Microglia by …
2021年11月15日 · Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, microglia promote the release of inflammatory mediators as well as promote phagocytosis.