KPC - 南模生物
KPC小鼠是一种携带KRAS和TP53基因突变的胰腺导管腺癌模型，具有自发性胰腺癌的特点，可用于胰腺癌的研究和治疗。本网页介绍了KPC小鼠的基因信息、品系描述、应用领域、疾病预测、验证数据和发表文献，以及相关的其他胰腺癌模型品系。
Differences between KC and KPC pancreatic ductal adenocarcinoma mice …
2020年1月1日 · This article reviews the differences between two genetically engineered mouse models of pancreatic cancer, KC and KPC, in terms of their modeling biology and clinical relevance. KC and KPC mice have distinct features and outcomes, and are not all suitable for preclinical studies.
Characterization of genetic subclonal evolution in pancreatic …
2019年11月28日 · The KPC mouse model, driven by the Kras and Trp53 transgenes, is well regarded for faithful recapitulation of human pancreatic cancer biology. However, the extent that this model...
KRAS drives immune evasion in a genetic model of pancreatic cancer - Nature
2021年3月5日 · Here, we use a mouse model of pancreatic ductal adenocarcinoma to inactivate KRAS by CRISPR-mediated genome editing. We demonstrate that at an advanced tumor stage, dependence on KRAS for...
Optimization of a mouse model of pancreatic cancer to simulate …
2024年4月4日 · The genetically engineered mouse model (GEMM), known as the KPC mouse (Pdx1-Cre, LSL-Kras +/G12D, LSL-Trp53 R172H/+), was shown to faithfully recapitulate the genetics and pathology of PDAC . In this model, the Pdx1 promoter drives Cre recombinase to express the lox-stop-lox (LSL) mutant Kras G12D gene, as well as the LSL mutant allele of Trp53 .
Differences between KC and KPC pancreatic ductal adenocarcinoma mice …
In this review, we focus on differences between two mice models K-ras LSL.G12D/+;Pdx-1-Cre(KC) and K-ras LSL.G12D/+; Trp53 R172H/+; Pdx-1-Cre(KPC) in terms of their modeling biology and their clinical relevance.
KPC-luciferase-expressing cells elicit an anti-tumor immune …
2024年6月13日 · In this study, we show that the expression of Luc in PDAC cells derived from the KPC mouse impacts the development of primary tumors and metastasis, in an orthotopic syngeneic model using ...
Abstract IA-007: The KPC model has helped advance pancreatic …
2021年11月15日 · This presentation will summarize the history and lessons learned from using the KPC mouse model and highlight impacts the model has had on pancreatic cancer therapy. We will focus in particular on the appropriate interpretation of preclinical results and understanding the similarities and differences between corresponding trials performed in ...
Modeling pancreatic cancer in mice for experimental therapeutics
2021年8月1日 · The median age of KPC mice was reported to be 24 weeks. KPC tumors closely mimic the complex TME of human PDAC, both pathologically and immunologically. Therefore, the KPC model has been widely used for the mechanistic understanding of PDAC progression and the optimization and preclinical evaluation of therapeutic approaches.
A Novel Immunocompetent Mouse Model of Pancreatic Cancer …
We have generated a novel mouse model of pancreatic cancer by implanting tumor fragments from KPC mice into the pancreas of wild type mice. Three-millimeter tumor pieces from KPC mice were implanted into the pancreas of C57BL/6J mice. Four to eight weeks later, tumors were harvested, and stromal and immune components were evaluated.