谷氨酸代谢 | Cell Signaling Technology
Xiao D, Zeng L, Yao K, Kong X, Wu G, Yin Y (2016) The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications. Amino Acids 48(9), 2067–80. 创建于 2018 年 1 月
The Many Roles of Glutamate in Metabolism - PMC - PubMed …
Glutamate plays a critical role in the central metabolism of many organisms, including nitrogen assimilation, amino acid biosynthesis, and cofactor production. It is also involved in the production of secondary metabolites such as antibiotics.
Glutamate metabolism and recycling at the excitatory synapse …
2021年9月15日 · In particular, we review the recently discovered role of neuronal glutamate uptake in synaptic glutamate homeostasis and discuss current advances in cellular glutamate metabolism in the context of Alzheimer's disease and Huntington's disease.
Metabolic pathways and activity-dependent modulation of glutamate …
Glutamate is a central compound in cellular metabolism and its carbon skeleton is diverted to many diverse anabolic and catabolic pathways. This can occur only after it is sequestered from the TCA cycle at the level of AKG, implying that anaplerotic reactions are required to prevent depletion of TCA cycle intermediates.
A pathway map of glutamate metabolism - PubMed
Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and ...
A pathway map of glutamate metabolism - Wiley Online Library
2015年12月3日 · Glutamate serves as an important precursor or substrate for synthesis of various amino acids, nucleic acids, nucleotides and metabolites. Availability of a comprehensive pathway map of glutamate metabolism will enhance our understanding of the role of various molecules involved in regulation of this pathway.
Biochemistry, Glutamate - StatPearls - NCBI Bookshelf
2022年12月19日 · Glutamate is metabolized through the tricarboxylic acid cycle in both neurons and astrocytes, albeit to different extents. Five high-affinity glutamate transporters are known: EAAT1 (GLAST), EAAT2 (GLT-1), EAAT3 (EAAC1), EAAT4, and EAAT5.
The many roles of glutamate in metabolism - PubMed
The amino acid glutamate is a major metabolic hub in many organisms and as such is involved in diverse processes in addition to its role in protein synthesis. Nitrogen assimilation, nucleotide, amino acid, and cofactor biosynthesis, as well as secondary natural …
The many roles of glutamate in metabolism - Oxford Academic
2016年3月1日 · Glutamate plays a critical role in the central metabolism of many organisms, including nitrogen assimilation, amino acid biosynthesis, and cofactor production. It is also involved in the production of secondary metabolites such as antibiotics.
2023年11月25日 · Glutamate metabolism comprises of several reversible and irreversible reactions. These reactions are catalyzed by en-zymes that are regulated by activators and inhibitors. For in-stance, conversion of L-glutamate to N-acetyl-L-glutamate in presence of N-acetylglutamate synthase (NAGS) is activated by L-arginine and inhibited by succinate ...