GSK126 (GSK2816126A) | EZH2抑制剂 - MCE
GSK126 (GSK2816126A) 是一种有效，选择性的 EZH2 甲基转移酶抑制剂， IC50 为 9.9 nM。 * Please select Quantity before adding items. • Cell. 2018 Sep 20;175 (1):186-199.e19. …
GSK-2816126(GSK-2816126) - 药物靶点：EZH2_在研适应症：去 …
最初是开发用于治疗ezh2激活突变的淋巴瘤，临床前研究中gsk2816126对ezh2表现出高选择性（超过ezh1的100倍），此外，gsk2816126在纳摩尔浓度下诱导体外癌细胞死亡，并在ezh2 …
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2
Dec 15, 2019 · Purpose: Enhancer of zeste homolog 2 (EZH2) activity is dysregulated in many cancers. Patients and methods: This phase I study determined the safety, maximum-tolerated …
GSK126 | 99.84%(HPLC) | Histone Methyltransferase inhibitor
May 22, 2024 · GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other …
- Reviews: 159
A phase I, open-label study of GSK2816126, an enhancer of zeste …
May 20, 2016 · GSK2816126, a selective and potent inhibitor of wild-type (WT) and mutant EZH2, can decrease H3K27me3 levels in vitro and has demonstrated antiproliferative activity in …
A Phase I Study of GSK2816126, an Enhancer of Zeste Homolog …
GSK2816126, a highly selective and potent inhibitor of both wild type (wt) and mutant (mut) EZH2, decreases H3K27 tri-methylation, releases transcriptional repression of PRC2 target genes …
A Phase I Study of GSK2816126, an Enhancer of Zeste
GSK2816126, a highly selective and potent inhibitor of both wild type (wt) and mutant (mut) EZH2, decreases H3K27 tri-methylation, releases transcriptional repression of PRC2 target genes …
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) …
Dec 13, 2019 · This phase I study determined the safety, maximum-tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of the intravenously administered, highly selective …
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) …
PURPOSE: Enhancer of zeste homolog 2 (EZH2) activity is dysregulated in many cancers. PATIENTS AND METHODS: This phase I study determined the safety, maximum-tolerated …
GSK126 | GSK2816126A | EZH2 甲基转移酶抑制剂 | TargetMol
GSK126 (GSK2816126A) 是一种 EZH2 甲基转移酶抑制剂 (IC50=9.9 nM)，具有有效性和选择性。 GSK126 具有抗肿瘤活性，可以抑制肿瘤细胞增殖、抑制血管生成。 MAK683 …
- Reviews: 10