GABA receptor agonist - Wikipedia
A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1]
GABA Receptor - StatPearls - NCBI Bookshelf
2023年2月13日 · GABA receptors are receptors that respond when GABA is released into the post-synaptic nerve terminal. They are considered the chief inhibitory receptors for the central nervous system. GABA receptors are subdivided into GABAa and GABAb.
GABA Receptor Physiology and Pharmacology - Basic …
Because GABA is widely distributed and utilized throughout the CNS, early GABAergic drugs had very generalized effects on CNS function. The development of more selective agents has led to the identification of at least two distinct classes of GABA receptor, GABA A and GABA B.
GABAA receptors: structure, function, pharmacology, and related ...
γ-Aminobutyric acid sub-type A receptors (GABA A Rs) are the most prominent inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion channel with significant physiological and therapeutic implications.
Physiology, GABA - StatPearls - NCBI Bookshelf
2023年7月24日 · GABA binds to two major post-synaptic receptors, the GABA-A and GABA-B receptors. The GABA-A receptor is an ionotropic receptor that increases chloride ion conductance into the cell in the presence of GABA. The extracellular concentration of chloride is normally much higher than the intracellular concentration.
GABAA receptors: structure, function, pharmacology, and …
2021年8月21日 · To date, few reviews have discussed GABA A receptors in detail. Accordingly, this review aims to summarize the current understanding of the structural, physiological, and pharmacological properties of GABA<sub>A</sub>Rs, as well as shedding light on the most common associated disorders.
GABA Agents - DrugBank Online
GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function. A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
Understanding the mechanism of action and clinical effects of ...
2023年6月26日 · Gamma-aminobutyric acid (GABA) is the key inhibitory neurotransmitter in the brain, working primarily via GABA A receptors, with an important role in virtually all physiologic functions in the...
GABA Agonists - DrugBank Online
Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA). A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. A sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
GABA Receptors: Pharmacological Potential and Pitfalls
Both types of receptors are targeted by many clinically important drugs that affect GABAergic function and are widely used in the treatment of anxiety disorder, epilepsy, insomnia, spasticity, aggressive behaviour, and other pathophysiological conditions and diseases.