dCMP deaminase - Wikipedia
dCMP deaminase (EC 3.5.4.12, deoxycytidylate deaminase, deoxy-CMP-deaminase, deoxycytidylate aminohydrolase, deoxycytidine monophosphate deaminase, deoxycytidine-5'-phosphate deaminase, deoxycytidine-5'-monophosphate aminohydrolase) is an enzyme which converts deoxycytidylic acid to deoxyuridylic acid.
ALR encoding dCMP deaminase is critical for DNA damage repair, …
2017年12月16日 · Deoxycytidine monophosphate deaminase (dCMP deaminase, DCD) is crucial to the production of dTTP needed for DNA replication and damage repair. However, the effect of DCD deficiency and its molecular mechanism are poorly understood in plants. Here, we isolated and characterized a rice albinic leaf an …
Discovery of deaminase functions by structure-based protein …
2023年7月20日 · Additionally, four deaminase families (deoxycytidylate monophosphate [dCMP], MafB19, LmjF365940, and APOBEC, as annotated by InterPro) were each divided into two separate clades when using structure-based clustering (Figures 1 C and 1D).
Deoxycytidine Phosphate Deaminase - an overview
Deoxycytidylate deaminase (DCTD) catalyzes the conversion of dCMP to dUMP in the deamination process, thus providing the nucleotide substrate for thymidylate synthase (TS). From: Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy , 2019
Deoxycytidine Phosphate Deaminase - an overview - ScienceDirect
Deoxycytidylate deaminase (DCTD) catalyzes the conversion of dCMP to dUMP in the deamination process, thus providing the nucleotide substrate for thymidylate synthase (TS). The gene coding for DCTD is localized on human chromosome 4, at locus 4q35.1 [80].
ALR encoding dCMP deaminase is critical for DNA damage repair, …
2017年11月24日 · ALR encodes a putative deoxycytidine deaminase protein in the cytidine deaminase (CDA)-like family that catalyses dCMP to dUMP and contains a deaminase catalytic motif and a Zn 2+ binding site. We conducted a comparative structural analysis of OsDCD and its homologous proteins.
Replication fork collapse and genome instability in a ... - PubMed
Ribonucleotide reductase (RNR) and deoxycytidylate deaminase (dCMP deaminase) are pivotal allosteric enzymes required to maintain adequate pools of deoxyribonucleoside triphosphates (dNTPs) for DNA synthesis and repair. Whereas RNR inhibition slows DNA replication and activates checkpoint responses, …
DCMP Deaminase - MeSH - NCBI - National Center for …
DCMP Deaminase. An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12. Year introduced: 1997. PubMed search builder ...
DCTD Gene - DCMP Deaminase
2024年12月24日 · DCTD (DCMP Deaminase) is a Protein Coding gene. Diseases associated with DCTD include Neutropenia and Pancreatic Cancer. Among its related pathways are pyrimidine deoxyribonucleotides biosynthesis from CTP and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include hydrolase activity and dCMP deaminase activity.
STRIPE2 encodes a putative dCMP deaminase that plays an
2014年10月20日 · ST2 belongs to the cytidine deaminase-like family and possibly functions as the dCMP deaminase, which catalyzes the formation of dUMP from dCMP by deamination. Additionally, exogenous application of dUMP could partially rescue the st2 phenotype.