What Are Cyclins? - News-Medical.net
2023年7月19日 · The cell cycle is regulated by cyclins, a type of protein that binds and activates cyclin dependent kinases (CDKs).
Cyclin - an overview | ScienceDirect Topics
Cyclins are a group of stress-sensitive proteins in controlling cell death and survival in DNA damage response. The B-type cyclin, i.e., cyclin B1, is an essential cell cycle component in the regulation of transition from G2 to M phase [127–130].
CDK | Learn Science at Scitable - Nature
Coordinated protein phosphorylation reactions control progression through the cell cycle. Learn how specific complexes of cyclins and cyclin-dependent kinases (CDKs) catalyze these reactions.
Core control principles of the eukaryotic cell cycle - Nature
2022年6月8日 · Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with different cyclin–CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs) 1,2.
Cyclin-dependent kinases | Genome Biology | Full Text
2014年6月30日 · Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
Function of cyclins in regulating the mitotic and meiotic cell cycles ...
2008年11月11日 · Several classes of cyclins have been described in mammalian cells, designated A to I, and also T. During the mitotic cell cycle, cyclins from the D-type family (D1, D2 and D3) regulate progression of cells through the G 1 phase. 10 D-type cyclins bind and activate Cdk4 and Cdk6.
Non-canonical functions of cell cycle cyclins and cyclin-dependent ...
2016年4月1日 · Mammalian cyclins and cyclin-dependent kinases (CDKs) have non-canonical, cell cycle-independent functions in processes such as transcription and DNA damage repair.
How the Cyclin Became a Cyclin - Cell Press
1999年5月14日 · With some debate, it is likely to be the discovery of cyclins and the cyclin-dependent kinases (Cdks) they regulate. Cyclins are key regulators of cell cycle transitions whose abundance varies through a cell cycle.
The Hunt for Cyclin - Cell Press
2008年7月25日 · It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
Cyclins and cyclin-dependent kinases: from biology to ... - Springer
2022年7月4日 · The discussion on cell proliferation cannot be continued without taking a look at the cell cycle regulatory machinery. Cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors (CKIs) are valuable members of this system and their equilibrium guarantees the proper progression of the cell cycle.
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