Mechanisms and regulation of cholesterol homeostasis
2019年12月17日 · Cholesterol is inserted into the limiting membrane of lysosome by coordinated actions of NPC2 and NPC1, followed by trafficking to downstream membranes including the plasma membrane and ...
Cholesterol in the Cell Membrane—An Emerging Player in …
Membrane cholesterol is essential for cell membrane properties, just as serum cholesterol is important for the transport of molecules between organs. This review focuses on cholesterol transport between lipoproteins and lipid rafts on the surface of macrophages.
Physiology, Cholesterol - StatPearls - NCBI Bookshelf
2023年3月6日 · Cholesterol is a lipophilic molecule that is essential for human life. It has many roles that contribute to normally functioning cells. For example, cholesterol is an important component of the cell membrane. It contributes to the structural makeup of the membrane as well as modulates its fluidity.
Biochemistry, Cholesterol - StatPearls - NCBI Bookshelf
2023年8月8日 · Cholesterol is a structural component of cell membranes and serves as a building block for synthesizing various steroid hormones, vitamin D, and bile acids. Besides their structural role providing stability and fluidity, cholesterol also plays a …
Cholesterol metabolism—physiological regulation and …
Cholesterol is found at the cell membrane and is enriched in the perinuclear area. The full picture represents a hepatic cell equally incubated with HDL containing Bodipy-cholesterol after diaminobenzidine photooxidation, which in turn leads to formation of electron-dense precipitate, enabling the visualization of fluorescent cholesterol itself ...
Cholesterol: The Plasma Membrane’s Constituent that Chooses …
2019年6月6日 · The most abundant sterol in the mammalian plasma membrane is cholesterol. Commonly reported numbers in literature suggest that cholesterol can in fact comprise up to 50% of the overall composition of the plasma membrane.
Cellular cholesterol trafficking and compartmentalization
Cholesterol is an essential structural component in the cell membranes of most vertebrates. The biophysical properties of cholesterol and the enzymology of cholesterol metabolism provide...
Nonuniversal impact of cholesterol on membranes mobility
2023年12月11日 · Remarkably, in unsaturated membranes, increased cholesterol mobility enhances cooperativity, resulting in membrane softening despite membrane thickening and lipid compression caused by...
The Structural Role of Cholesterol in Cell Membranes: From …
2014年10月13日 · Despite extensive studies with model membranes, two fundamental issues have remained a mystery: (i) the mechanism by which cholesterol condenses low-melting lipids by uncoiling their acyl chains and (ii) the thermodynamics of the interaction between cholesterol and high- and low-melting lipids.
Cholesterol transport between cellular membranes: A balancing …
2021年5月17日 · Cholesterol is an essential component of mammalian cell membranes. All nucleated cells are capable of synthesizing it de novo from the central two-carbon metabolic precursor acetate that is processed to the unique 27-carbon, four-ring structure via a complex series of enzyme reactions.