Brain stimulation-on-a-chip: a neuromodulation platform for brain slices
2023年10月30日 · This on-chip bioelectronic platform presents a modernized yet simple solution to electrically stimulate explanted tissue by offering more environmental control to users, which unlocks new opportunities to conduct thorough brain stimulation mechanistic investigations.
Brain stimulation-on-a-chip: a neuromodulation platform for brain slices
2023年11月15日 · Therefore, we developed an on-chip platform with fluidic, electrochemical, and magnetically-induced spatial control. Fluidically, the chamber geometrically confines precise dcEF delivery to the enclosed brain slice and allows for tissue recovery in order to monitor post-stimulation effects.
Brain slice on a chip: opportunities and challenges of applying ...
Isolated brain tissue, especially brain slices, are valuable experimental tools for studying neuronal function at the network, cellular, synaptic, and single channel levels. Neuroscientists have refined the methods for preserving brain slice viability and function and converged on principles that strongly re Focus on USA
Unraveling brain diseases: The promise of brain-on-a-chip models
2024年3月8日 · Brain-on-a-Chip (BoCs) models are promising for studying neurological diseases. The review examines BoCs' impact on stroke, Alzheimer’s, Parkinson’s, and epilepsy. We discuss the main benefits and challenges of BoCs.
Alternative Brain Slice-on-a-Chip for Organotypic Culture and
2022年2月25日 · This report presents an alternative brain slice-on-a-chip, integrating an injection system inside the chip to dispense a fluorescent dye for long-term monitoring. Hippocampal slices have been cultured inside these chips, observing fluorescence signals from living cells, maintaining the cytoarchitecture of the slices.
Brain slice on a chip: Opportunities and challenges of applying ...
2012年4月25日 · Isolated brain tissue, especially brain slices, are valuable experimental tools for studying neuronal function at the network, cellular, synaptic, and single channel levels.
Alternative Brain Slice-on-a-Chip for Organotypic Culture and …
2022年2月25日 · This report presents an alternative brain slice-on-a-chip, integrating an injection system inside the chip to dispense a fluorescent dye for long-term monitoring. Hippocampal slices have been cultured inside these chips, observing fluorescence signals from living cells, maintaining the cytoarchitecture of the slices.
2023年4月14日 · Here we developed a plat- form with fluidic, electrochemical, and magnetically-induced spatial control. Fluidically, the chamber geometrically confines precise dcEF delivery to the enclosed brain slice and allows for tissue recovery in order to monitor post-stimulation effects.
Alternative Brain Slice-on-a-Chip for Organotypic Culture and
2022年2月25日 · This report presents an alternative brain slice-on-a-chip, integrating an injection system inside the chip to dispense a fluorescent dye for long-term monitoring. Hippocampal slices have been cultured inside these chips, observing fluorescence signals from living cells, maintaining the cytoarchitecture of the slices.
On the road to the brain-on-a-chip: a review on strategies, …
2021年8月12日 · In this review, we will discuss the state of the art of the brain-on-a-chip, highlighting which structural and biological features a realistic in vitro brain should embed (and how to achieve them). In particular, we identified two topological features, namely modular and three-dimensional connectivity, and a biological one (heterogeneity) that ...