Acetylcholinesterase: From 3D Structure to Function - PMC
By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction.
21.6: Chemistry of Esters - Chemistry LibreTexts
Like many other hydrolytic enzymes, the acetylcholinesterase reaction proceeds in two phases: first, a covalent enzyme-substrate intermediate is formed when the acyl group of acetylcholine is transferred to an active-site serine on the enzyme (a transesterification reaction).
Catalytic Reaction Mechanism of Acetylcholinesterase Determined …
2010年7月8日 · Acetylcholinesterase (AChE) is a remarkably efficient serine hydrolase responsible for the termination of impulse signaling at cholinergic synapses. By employing Born-Oppenheimer molecular dynamics simulations with B3LYP/6-31G (d) QM/MM potential and the umbrella sampling method, we have characterized its complete catalytic reaction mechanism ...
7.12: Hydrolysis of Thioesters, Esters, and Amides
Acetylcholinesterase (EC 3.1.1.7), an enzyme present in the synapse, catalyzes hydrolysis of the ester group in acetylcholine, a neurotransmitter that triggers muscle contraction.
Physiology, Acetylcholinesterase - StatPearls - NCBI Bookshelf
2023年1月19日 · Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally …
Acetylcholinesterase: Mechanism of Catalysis and Inhibition
2001年8月1日 · The active site gorge of acetylcholinesterase, containing multiple potential substrate binding areas, is responsible for trapping and delivery of substrate molecules to the active site.
Acetylcholinesterase - an overview | ScienceDirect Topics
Acetylcholinesterase (AChE) is a serine protease degrades acetylcholine between cholinergic synapses and terminates cholinergic neural signaling (Silman and Sussman 2008). Studies have revealed that AChE activity was reduced in PD patients with cognitive impairment, and the loss of cholinergic was observed within the central and peripheral ...
Acetylcholinesterase - SpringerLink
2018年1月1日 · Acetylcholinesterase is a serine hydrolase that cleaves choline esters rapidly, preferentially acetylcholine (ACh). AChE shows a great ACh-hydrolyzing capacity, and in the list of enzymes classified according to their catalytic efficiency AChE occupies the second position.
Acetylcholinesterase — new roles for an old actor - Nature
b | The acetylcholinesterase (AChE) reaction. AChE promotes acetylcholine hydrolysis by forming an acetyl-AChE intermediate with the release of choline, and the subsequent hydrolysis of the...
Acetylcholinesterase: from 3D structure to function - PubMed
2010年9月6日 · By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction.
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