ATP from synaptic terminals and astrocytes regulates NMDA …
2016年9月19日 · ATP released from astrocytes facilitates a recruitment of P2X receptors into excitatory synapses by Ca 2+ -dependent mechanism. P2X receptors, co-localized with NMDA receptors in the excitatory...
Energy matters: presynaptic metabolism and the maintenance …
2020年10月5日 · Synaptic activity imposes large energy demands that are met by local adenosine triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative phosphorylation. ATP drives action...
Synaptic Energy Use and Supply - ScienceDirect
2012年9月6日 · We will review how most brain energy is used on synapses, investigate how pre- and postsynaptic terminals are optimized to maximize information transmission at minimum energy cost, and assess how ATP provision to synapses is regulated to …
Synaptic Energy Use and Supply - Cell Press
2012年9月6日 · We will review how most brain energy is used on synapses, investigate how pre- and postsynaptic terminals are optimized to maximize information transmission at minimum energy cost, and assess how ATP provision to synapses is regulated to …
The Role of Mitochondrially Derived ATP in Synaptic Vesicle …
2015年9月9日 · The first is a functional assay for mitochondrially derived ATP that uses the extent of synaptic vesicle cycling as a surrogate for ATP level. The second uses ATP FRET sensors to directly measure ATP at the synapse.
Activity-driven local ATP synthesis is required for synaptic function
The development of Syn-ATP has allowed us to probe several important aspects of the regulation and consumption of ATP in nerve terminals as we demonstrate: 1) activity contributes significantly to ATP consumption; 2) activity stimulates ATP synthesis; 3) the synaptic vesicle cycle presents a large burden to ATP supplies at presynaptic sites ...
Molecular physiology of p2x receptors and atp signalling at synapses
2001年3月1日 · Here I discuss the 'fast' actions of ATP at synapses, the properties of the receptors that are activated by ATP and the physiology of ATP signalling, with emphasis on its role in pain...
Modulation of Central Synapses by Astrocyte-Released ATP and ...
2017年8月6日 · Recent data show that postsynaptic P2X receptors underlie slow neuromodulatory actions rather than fast synaptic transmission at brain synapses. Here, we review these findings with a particular focus on the release of ATP by astrocytes and the diversity of postsynaptic P2X-mediated modulation of synaptic strength and plasticity in the CNS. 1.
How astrocytic ATP shapes neuronal activity and brain circuits
2023年4月1日 · Astrocytic ATP may serve to synchronise brain activity across brain areas and match neuronal excitability to energy demands. Astrocytes play a key role in processing information at synapses, by controlling synapse formation, modulating synapse strength and terminating neurotransmitter action.
Astrocytes contribute to synapse elimination via type 2 inositol …
2016年4月12日 · Our results uncovered a novel mechanism suggesting that astrocytes release ATP in an IP3R2-dependent manner to regulate synapse elimination. Neighbouring neurons connect to each other and share information through structures known as synapses. As the brain develops, many synapses turn out to be redundant.