Adeno-associated Virus (AAV) Guide - Addgene
Learn about the structure, life cycle, and applications of adeno-associated virus (AAV), a popular vector for gene delivery and optogenetics. Find out how to choose the best serotype and pseudotype for your experimental needs.
Adeno-associated virus as a delivery vector for gene therapy
2024年4月3日 · Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different...
Viral Vectors 101: An Introduction to AAV - Addgene
2023年5月30日 · Learn about AAV, a non-pathogenic, non-integrating virus that can be used to express genes of interest in cell and animal models. Find out how to choose the right AAV serotype, promoter, and gene switch for your experiment.
AAV Vector Immunogenicity in Humans: A Long Journey to …
AAV vectors are broadly utilized tools for in vivo gene therapy. Yet, the human immune system poses important challenges to the use of this platform. The complex interplay of innate and adaptive immunity, to both vector components and transgene product, appears to be a key determinant of the outcomes in gene transfer trials.
Adeno-associated virus vector as a platform for gene therapy
2019年2月1日 · Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically...
Engineering adeno-associated virus vectors for gene therapy
2020年2月10日 · Adeno-associated virus (AAV) vector-mediated gene delivery was recently approved for the treatment of inherited blindness and spinal muscular atrophy, and long-term therapeutic effects have...
AAV vectors: The Rubik's cube of human gene therapy
2022年12月7日 · In the present review, we address the different approaches to improve AAV vectors for gene therapy with a focus on AAV capsid selection and engineering, strategies to overcome anti-AAV immune response, and vector genome design, ending with a glimpse at vector production methods and the current state of recombinant AAV (rAAV) at the clinical level.
Adeno-associated virus vector as a platform for gene therapy ... - PubMed
Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids, optimizing genome designs and harnessing revolutionary biotechnologies have contributed substantially to t …
Adeno-associated Virus (AAV): Structure, Vector, Gene Therapy,
Learn about the history, discovery, classification, and applications of AAV, a viral vector for gene delivery. Find out how AAV serotypes differ in their tissue tropism, production, and challenges for gene therapy.
AAV vectors: The Rubik’s cube of human gene therapy - Cell Press
In the present review, we address the different approaches to improve AAV vectors for gene therapy with a focus on AAV capsid selection and engineering, strategies to overcome anti-AAV immune response, and vector genome design, ending with a glimpse at vector production methods and the current state of recombinant AAV (rAAV) at the clinical level.
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