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α-Synuclein in Parkinson's Disease - PMC - PubMed Central (PMC)
Abstract. α-Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD pathogenesis in a number of ways, but it is generally thought that its aberrant soluble oligomeric conformations, termed protofibrils, are the toxic species that mediate disruption of cellular homeostasis and neuronal death ...
Alpha-synuclein in Parkinson’s disease and other ... - Nature
Mar 1, 2023 · The discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) was postulated more than twenty years ago [1, 2] when genetic forms of PD were described.
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