Unveiling Colitis: A Journey through the Dextran Sodium Sulfate …
2024年1月27日 · Unlike oxazolone and TNBS, which are small molecules, DSS is a sulfated polysaccharide that can have a variable molecular weight (MW). Therefore, the DSS-induced colitis model involves a pathogenic mechanism different from those induced by hapten reagents such as oxazolone and TNBS.
Dextran sulfate sodium (DSS)-induced colitis in mice - PubMed
2014年2月4日 · Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed.
Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks
Furthermore, studies that validated DSS model by using different therapeutic agents for human IBD show that DSS-induced colitis can be used as a relevant model for the translation of mice data to human disease . Thus, the aim of the present paper is to give a concise introduction of different factors that may be involved in the patogenesis of ...
Gut microbiota drives disease variability in the DSS colitis mouse model
2022年4月22日 · Analysis of the mice ten days post-DSS treatment revealed considerable differences in intestinal pathology and weight change between mice from different parental lineages, which confirmed...
Chemically induced mouse models of acute and chronic ... - Nature
2014年6月8日 · In TNBS and oxazolone colitis models, topical administration of hapten reagents results in T-cell-mediated immunity against haptenized proteins and luminal antigens. By contrast, to generate DSS...
The reduction of DSS-induced colitis severity in mice exposed to ...
2020年3月2日 · In the present study, we combined a validated UC mouse model (dextran sulfate sodium, DSS) and a well-controlled inhalation exposure design with disease-specific endpoints and system-wide...
Selection strategy of dextran sulfate sodium-induced acute or …
2021年10月16日 · Dextran sulfate sodium (DSS) replicates ulcerative colitis (UC)-like colitis in murine models. However, the microbial characteristics of DSS-triggered colitis require further clarification. To analyze the changes in gut microbiota …
Kaempferol relieves the DSS-induced chronic colitis in C57BL/6J mice …
2023年8月1日 · Changes in proteins related to the VEGF pathway in the DSS-induced mouse model of colitis are consistent with those found in human colitis.
Expanding the utility of the dextran sulfate sodium (DSS) mouse model ...
2020年3月10日 · Many animal studies of IBD use a dextran sulfate sodium (DSS) mouse model of colitis that induces rapid and severe colitis symptoms.
Acute dextran sulfate sodium (DSS)-induced colitis promotes gut ...
We investigated fecal and colonic mucosa microbial composition and functional changes in mice treated with DSS. C57Bl/6 mice received 5% DSS in drinking water for 5 days. Inflammation was evaluated clinically and by analysis of colonic tissue cytokine levels and …