Recent progress in ferroptosis: inducers and inhibitors
2022年12月29日 · Ferrostatin-1 (Fer-1) was identified as a ferroptosis inhibitor by Dixon et al. in 2012, which was proved to inhibit RSL3 or erastin induced ferroptosis in HT-1080 cells.
Ferroptosis: past, present and future - Cell Death & Disease
2020年2月3日 · The application of the ferroptosis inhibitor Fer-1 significantly reduces iron deposition, neuronal degeneration, and injury and improves the prognosis of patients, thus providing an...
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
2023年12月1日 · In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, pharmacokinetic, and pharmacological properties and potential for in vivo use is provided. Previous. ferroptosis inhibitors.
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
2023年9月26日 · Although, novel biochemical pathways provide insights for different pharmacological targets, the use of lipophilic RTAs to block ferroptosis remains superior. In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs.
Ferroptosis inhibitors: past, present and future - PubMed
2024年5月23日 · Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of …
Recent progress in ferroptosis: inducers and inhibitors
2022年12月29日 · This paper briefly introduces important regulatory targets in the ferroptosis metabolic pathway, lists and categorizes commonly used and recently developed inducers and inhibitors, and discusses their medical application.
Ferroptosis: Emerging mechanisms, biological function, and …
2024年1月24日 · Ferroptosis, a distinct form of cell death, plays a crucial role in inhibiting tumor growth and has opened new avenues for treating chemotherapy-resistant tumors. A mounting body of research has...
Ferroptosis Inhibition: Mechanisms and Opportunities - Cell …
2017年3月28日 · We review here advances in our understanding of the ferroptotic process and summarize the development of lipid peroxidation inhibitors with the ultimate goal of suppressing ferroptosis-relevant cell death and related pathologies.
Ferroptosis Inhibitors as Potential New Therapeutic Targets for ...
The iron, lipid, amino acid, and glutathione metabolisms strictly govern the beginning and execution of ferroptosis. Therefore, ferroptosis can be inhibited by iron chelators, free radical-trapping antioxidants, GPX4 (Glutathione Peroxidase 4) activators, and …
Ferroptosis turns 10: Emerging mechanisms, physiological …
2022年7月7日 · Small molecule inhibitors, lipids, and metabolite structures are shown and labeled in green for those that suppress ferroptosis, red for those that induce ferroptosis, and purple for those that neither promote nor suppress ferroptosis.
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