Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

Background Intestinal fibrosis resulting in stricture formation and obstruction in Crohn’s disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is among the largest ...

Correspondence to Dr Jun Yu, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Chinese University of Hong Kong, New Territories, Hong Kong; junyu{at}cuhk.edu.hk The gut ...

Objective Autophagy participates in the progression of hepatocellular carcinoma (HCC) and the resistance of HCC cells to sorafenib. We investigated the feasibility of sensitising HCC cells to ...

aDepartment of Gastrointestinal Medicine, Royal Adelaide Hospital, Adelaide, Australia, bSödra Hõlsocentralen, Hudiksvall, Sweden, cUniversity of Michigan Health ...

Correspondence to Dr Tony Hsiu-Hsi Chen, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan; chenlin{at}ntu.edu.tw Objective To ...

Correspondence to Dr Kathleen E DelGiorno, Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37212, USA; kathleen.delgiorno{at}vanderbilt.edu; Dr Oren Parnas, Lautenberg Center for ...

Background Obesity is associated with accumulation of macrophages in white adipose tissue (WAT), which contribute to the development of insulin resistance. Germ-free (GF) mice have reduced adiposity ...

Objective Cirrhotics have a high rate of infections, which are increasingly fungal or culture-negative in nature. While infected cirrhotics have bacterial dysbiosis, the role of fungi is unclear. We ...

1 Division of Gastroenterology, and Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA 2 Department of Psychiatry, Washington University School of Medicine, St ...

Design We performed liquid chromatography and tandem mass spectrometry (LC–MS/MS) untargeted analysis of 40 human CRC and normal paired samples and targeted, quantitative analysis of 81 human CRC and ...

Immune checkpoint inhibitors (ICI) have led to breakthrough improvements in the management of malignancy including hepatocellular (HCC) and biliary tract cancer, improving decades-old standards of ...