Cells prefer ACLY but, in the event of problems, ACSS2 picks up the slack to ensure a continual supply of acetyl-CoA. Although this type of "metabolic flexibility" has been observed in cancer ...

For example, Eubacterium limosum is an acetogen, a microorganism that can convert carbon monoxide (CO) or CO 2 to acetate via a unique metabolic pathway in which acetyl coenzyme A (acetyl-CoA ...

the metabolic enzyme determined the location of acetyl-CoA, (3) the location of acetyl-CoA determined what gene-modifying histone acetyltransferases were activated, and (4) those histone ...