This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

在日常生活中，吸烟的危害如影随形，时刻威胁着人们的健康。那袅袅升起的烟雾中，隐藏着诸多致病因子，而尼古丁作为香烟的关键成分，更是备受瞩目。你是否想过，它在进入人体后，会在我们的肠道深处悄然引发怎样的“蝴蝶效应”呢？近期Elife的一项重磅研究Nico ...

Jan. 15, 2025 — While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows.

Thus, there is an urgent need for more effective therapeutic strategies that minimize side effects. The Hippo-YAP/TAZ signaling pathway plays a pivotal role in regulating stem cell fate, tissue ...

The study shows for the first time the capacity of these particles to be absorbed by human intestinal cells, and are thus able to reach the bloodstream and spread throughout the body. Plastic ...

Department of Medicine, University of Erlangen-Nuremberg, Hartmannstrasse 14, 91 054 Erlangen, Germany; christoph.becker{at}uk-erlangen.de Intestinal epithelial cells (IEC) are organised as a single ...

The researchers then tested whether mucus-producing cells derived from human intestines took up these particles in culture over a 24-hour period. The authors were unable to establish any ...

A: Animal; ACE: Accessory cholera enterotoxin; H: Human; ZOT: Zonula occludens toxin.

Darryl Yap is further speaking up about his controversial movie “The Rapists of Pepsi Paloma,” as he revealed that its storyline is based on the accounts of the late sexy star’s family.