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Large-scale genomic sequencing of melanoma has identified bona fide activating mutations in RAC1, which are associated with resistance to BRAF-targeting therapies. Targeting the RAC1-GTPase pathway, ...

In this important study, the authors found, with the use of statistical methods, that compound heterozygous rare deletion variants affecting the kinase-domain of non-receptor tyrosine kinase TNK2/ACK1 ...

Fixatives used in this study were glutaraldehyde (0.2% glutaraldehyde, 0.4% paraformaldehyde, 2mM MgCl 2 in PBS) for X-gal staining, and paraformaldehyde (4% PFA in PBS) for immunofluorescence ...