These molecules activate downstream signaling pathways such as NF-κB, MAPK, etc., by binding to receptors such as TLR ... Ubiquitination controls the onset of necrotic apoptosis by regulating the ...

State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China ...

Poly-ubiquitin chains associate (5) and activate TAB2/3/TAK1 kinases (6). Trifosome is primed with TLR ligand binding (1a). Associated TRAM and TRIF (2a) activate TRAF3 directly (3a) and TRAF6 in a ...

Furthermore, Faim2 gene knockout significantly exacerbated cardiac hypertrophy and heart fibrosis in vivo. Mechanistic investigations unveiled that FAIM2 exerts its inhibitory effect by suppressing ...

Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York 10065, United States Tri-Institutional PhD Program in Chemical Biology, New York, New York 10065, ...