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生物谷
1 个月
Commun Chem:新研究揭示突变的p53 蛋白促进p63和p73转化为癌症促进因子 ...
正常的p53可以形成功能性生物分子凝聚物,而这些突变体则大大加快了向固态、淀粉样状态的转变。这种转变通过一种类似朊病毒(prion)的机制 ...
Nature
11 个月
p53 : The Most Frequently Altered Gene in Human Cancers
p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
生物谷
27 天
脑细胞的救赎?Nature新研究:靶向神经纤维化的抑制剂有望阻止肥胖 ...
其中,S100A6+ EMT亚型具有以EMT上调和缺氧为特征的促转移表型,并伴有TGF-β-SMAD通路的激活。 本研究探索了氧化应激诱导癌细胞转移的机制,发现ros ...
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