This study addresses fundamental questions surrounding otitis media effusion in Down syndrome, identifying DYRK1A as a key gene involved in the condition. The findings are compelling, highlighting ...

I basically announced minecraft 2. I thought that maybe people ACTUALLY do want me to make another game that's super similar to the first one, and I'm loving working on games again. I don ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...

This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the ...

We thus generated a Notch (intracellular Notch 1, ICN1)-induced T-ALL mouse model, in which conditional Cn genetic deletion is restricted to leukemic cells. Ex vivo, Cn deletion altered the ...

Each monthly podcast delivers a quick update on key highlights from the journal’s current issue and expert insights into new research that will have an impact in the field.

In a tradition dating back to 1960, residents of Dixville Notch, New Hampshire, cast their ballots at the stroke of midnight (05:00 GMT). The remote, unincorporated resort town opened its polling ...

In bioinformatic analyses, ACAT1’s inhibitory effect on gastric cancer may be related to the Adipocytokine Signaling Pathway, the Ppar Signaling Pathway, propanoate metabolism, and the P53 Signaling ...

Cells must be able to interpret signals they encounter and reliably generate an appropriate response. It has long been known that the dynamics of transcription factor and kinase activation can play a ...