Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient p53-independent cell cycle delay. These studies highlight the distinct effects ...

This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the ...

I basically announced minecraft 2. I thought that maybe people ACTUALLY do want me to make another game that's super similar to the first one, and I'm loving working on games again. I don ...

We thus generated a Notch (intracellular Notch 1, ICN1)-induced T-ALL mouse model, in which conditional Cn genetic deletion is restricted to leukemic cells. Ex vivo, Cn deletion altered the ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...

Correspondence to Professor Ursula Fearon, Department of Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin D4, Ireland; fearonu{at}tcd.ie Objectives This ...

2022). Notch glycosylation is unique; the Notch signaling pathway is crucial for cell fate decisions, and its imbalance can lead to a variety of human diseases. Glycosylation of the extracellular ...

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) constitutes a critical therapeutic approach for patients with malignant hematological disorders. Nevertheless, acute graft-versus-host ...

It is formed by a thick column of parakeratotic cells extending outward from a notch in the malpighian layer of the epidermis and forms the raised ... Fatal outcomes from disseminated squamous cell ...

Background Aberrant Wnt pathway activation is a key driver of colorectal cancer (CRC) and is essential to sustain tumour growth and progression. Although the downstream protein-coding target genes of ...