By fully substituting the RNA with modified nucleotides, they successfully reduced inflammatory responses, resulting in enhanced performance of a COVID-19 vaccine with efficacy at 100X lower doses ...

micro RNAs (miRNAs) are a type of non-coding RNA (ncRNA), ~21 24 nucleotides in length, that function in the post-transcriptional regulation of gene expression. Typically miRNAs interact with ...

We’re at this tipping point” for AI in biology, Eran Segal, a computational biologist at the Weizmann Institute of Science ...

Combining a weakly hydrophobic ion-pairing agent with a moderately hydrophobic one further improved resolution.

This important theoretical study examines the possibility of encoding genomic information in a collective of short overlapping strands (e.g., the Virtual Circular Genome (VCG) model). The study ...

Anchoring the west side of Indianapolis, the White River State Park offers 250 acres of green space dotted with memorials and museums as the Central Canal and the White River offer waterways in ...

Guillarme recently spoke with LCGC International about his work analyzing therapeutic oligonucleotides. What are oligonucleotides? How do they differ from nucleotides? What is their benefit?

Imagine you're a scientist, tasked with the challenge of rapidly producing large quantities of high-quality messenger RNA (mRNA) for use in cutting-edge medical treatments. Where do you even start?

Snake zodiac leaders drive pharma and bio growth in South Koreas 2025 economy Zodiac leaders fuel pharmaceutical and ...

DOI: 10.1038/s41586-024-07559-x The system was trained on a pseudo-structure database covering a broad range of RNA folds and tested on multiple RNAs that exceeded 200 nucleotides in length (RNase ...

“The more we look, the crazier we see,” said Mark Peifer, a cell and developmental biologist at the University of North Carolina. They resemble what scientists call viroids, which are infectious loops ...