In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

aCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, ...

Rationalized selection of responsive TCR clones by single-cell analysis to aid in the generation of novel TCR transgenic animals.

Ferroptosis is involved in the involution of hemangiomas. Glutathione peroxidase 4‐mediated ferroptotic resistance in macrophages, which could be promoted by hemangioma‐derived stem cells, occurs in ...

pro-inflammatory macrophage; PPARδ, peroxisome proliferator-activated receptor delta; NF-κB, nuclear factor kappa B; ROS/RNS, reactive oxygen species/reactive nitrogen species; VEGF, vascular ...

This month's cover highlights the article A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets by Stacey D. Gilk, Rajendra Angara and Arif Sadi. The ...

KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage. Mitochondrial hyperfusion induces metabolic ...

Transcriptional factor Nrf2, enriched in astrocytes, is a master regulator of endogenous defense systems against oxidative stress and inflammation. Korean Red Ginseng (Ginseng), one most widely used ...