Zai Lab Limited today announced that China's National Medical Products Administration (NMPA) has accepted the New Drug Application (NDA) for KarXT for the treatment of schizophrenia in adults. "There ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Drugs for metabolic diseases, vaccines, and cancer therapies feature among new product launches this year that could top $1 ...

The drug candidate acts by targeting muscarinic acetylcholine receptor M4. The drug candidate is a positive allosteric modulator, or PAM. It is administered through oral route as tablets. It was also ...

The strength of the evidence is incomplete and could be improved by changes in task design and analyses, cross-validation of the conditions in calcium imaging, as well as the incorporation of control ...

Department of Biomedical Engineering, University of West Attica, Ag. Spyridonos, Egaleo 12243, Greece ...

Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States Department of Structural Biology, University of Pittsburgh, Pittsburgh, ...

It is administered through oral route as tablets and through intravenous route. It acts by targeting Muscarinic Acetylcholine Receptor M1 (CHRM1). It was also under development for the treatment of ...

Other prescription treatment options include Botox (onabotulinumtoxinA), beta-3 adrenergic agonists, estrogen, muscarinic receptor antagonists, and certain types of antidepressants. In some cases, ...

Xanomeline and trospium is a medication that works in the brain to treat schizophrenia. It is a first medication in this new class, offering an approach by selectively activating small proteins in the ...