and activation of the mitochondrial permeability transition pore. The release of mitochondrial DNA (mtDNA), recognized as damage-associated molecular patterns, can activate the cGAS-STING1 and NF-κB ...

These channels, including various potassium channels, the calcium uniporter, and the mitochondrial permeability transition pore, play crucial roles in both physiological and pathological processes.

In this chapter, we analyze the progress in the traffic of lipids between ER and mitochondria and we highlight the remaining unexplored questions. Most of the advances so far have been obtained in ...

Mitochondria are now known to not only generate energy but also produce essential cellular materials, adapting uniquely to stress, which sheds light on cancer survival tactics and aging processes.

1,3 In recent years, mitochondrial dysfunction has become a possible mechanism that could explain the development of sarcopenia. Transformations in mitochondria function are seen before the loss ...

The mitochondria act as the energy factories of our cells, creating ATP that drives our bodily functions. Inefficiencies in mitochondrial function have been associated with a variety of health ...

The mitochondrial genome is the full genetic complement of a mitochondrion. Mitochondrial DNA is only a small portion of the total DNA of a eukaryotic cell and in most species is solely inherited ...

A growing body of evidence now indicates that mitochondrial dysfunction and oxidative stress have central roles in PD pathogenesis. Recent advances in understanding the genetics of PD in humans ...

The McNair Medical Institute at Baylor College of Medicine was established in 2007 to recruit talented scientists and physician-scientists from around the world to the Texas Medical Center. These ...

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