Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal ... cell growth, prevention of apoptosis, tumor invasion and neo-angiogenesis. Sorafenib is an oral multikinase inhibitor ...

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil ...

Discover how low-dose lisinopril, an ACE inhibitor, could revolutionize male infertility treatments. This article explores ...

He, H.J., Cen, X.H., Liang, Y.J., Zhong, J.M., Deng, J.H. and Jiang, Y.J. (2025) Progress in the Regulation of Lipid Metabolism by the Orphan Nuclear Receptor Nur77. Journal of Biosciences and ...

Nitto BioPharma, Inc., San Diego, California.

This manuscript offers valuable insights by identifying two distinct liver cancer subtypes through multi-omics integration and developing a robust prognostic model, validated across various datasets, ...

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Inhibition of mitogen-activated protein kinase (ERK, JNK and p38 kinase) signalling in PSC mediates the induction of quiescence in response to retinol and retinoic acid. There is some evidence that ...