Discover how lithocholic acid, a key calorie-restriction metabolite, unlocks the secret to improved health, stronger muscles, ...

相关工作分别以“Lithocholic acid phenocopies anti-ageing effects of calorie restriction”和“Lithocholic acid binds TULP3 to activate sirturins and AMPK to slow down ageing”为题，以两篇Article的篇幅，发表在Nature期刊上 ...

在这项新的研究中，这些作者着重关注石胆酸（LCA），这是一种由肠道细菌产生的胆汁酸。 在两项新的研究中，来自中国厦门大学、中国科学院和 ...

Lithocholic acid (LCA) is a hepatotoxic compound. Fetal LCA might play a role in the pathogenesis of neonatal cholestasis/EHBA. Recent results show that fetal liver has capacity for hydroxylations ...

A team of scientists in China said they have discovered how a type of bile known as lithocholic acid (LCA) can slow down ageing in a way similar to how calorie restriction or fasting work.

Read the paper: Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing Generally speaking, bile is less interesting than is longevity, but that might soon change.

Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

In a new study, published in the journal Nature on Thursday, the scientists assessed the effects of lithocholic acid, or LCA, in genetically modified mice with human tissues and compared them to ...

Our demonstration of a potent anti-tumor effect of lithocholic acid in cultured human cancer cells and our identification of the mechanisms underlying such effect of lithocholic acid has been ...

For this new study, the team focused their efforts on lithocholic acid (LCA), a bile acid created by bacteria in the gut. Prior research had suggested that LCA was a toxin, but more recently ...

LCA can boost muscle regeneration and enhance grip strength. In a pioneering study published in the journal Nature, Chinese scientists have identified a naturally produced bile, lithocholic acid ...