Within 4 hours of the first dose, defecation occurred in 48% of methylnaltrexone patients and in 15% of the placebo patients. Constipation is common among people who take opioids chronically.

Rizmoic is a once-daily 200-microgram oral tablet for the treatment of opioid induced constipation (OIC) in adult patients previously treated with a laxative. Shionogi received EU marketing ...

As “appropriate therapeutic management” for opioid induced constipation, the author names a combination of oxycodone with naloxone, or methylnaltrexone, and finally (!) laxatives. I have ...