Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

A theoretical benefit of insulin abuse by body builders is that it is undetectable by currently available tests. A case is presented that highlights the dangers of such abuse. It is well publicised ...

Let’s not demonize carbohydrates and insulin. Carbohydrates are beneficial for fueling the body for exercise and demanding ...

Exenatide activates the GLP-1 receptor, thereby increasing intracellular cyclic AMP (cAMP) in beta cells leading to glucose-dependent insulin synthesis and release. Additionally, it also decreases ...

Figure 1: The signalling pathway by which insulin inhibits GSK3 and contributes to the stimulation of glycogen and protein synthesis. Figure 4: The molecular mechanism by which phosphorylation ...

Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis. Instruct patients on proper administration of insulin, check insulin label before each injection, and management of ...