Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

A theoretical benefit of insulin abuse by body builders is that it is undetectable by currently available tests. A case is presented that highlights the dangers of such abuse. It is well publicised ...

Figure 1: The signalling pathway by which insulin inhibits GSK3 and contributes to the stimulation of glycogen and protein synthesis. Figure 4: The molecular mechanism by which phosphorylation ...