This three-step pathway involves the enzymes carboxylesterase, cytidine deaminase and thymidine phosphorylase (Figure 1), all of which are expressed in hepatic and tumor tissue. In particular the ...

The gut microbiome, or the community of microorganisms residing in the gastrointestinal tract, has emerged as an important ...

Decitabine is a cytidine antimetabolite analogue that inhibits DNA methyltransferase-1. E-7727 is a new molecular entity (NME) that inhibits cytidine deaminase (CDA) activity. It is developed based on ...

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China ...

Correspondence to Dr Jun Yu, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Chinese University of Hong Kong, New Territories, Hong Kong; junyu{at}cuhk.edu.hk The gut ...

Centre for Proteomic Research, School of Biological Sciences and Institute for Life Sciences, University of Southampton, Building 85, Southampton SO17 1BJ ,U.K. Centre for Cancer Immunology and ...

Correspondence to Professor Dr Thomas Gress, Division of Gastroenterology, Endocrinology, Infectiology and Metabolism, University Hospital Giessen and Marburg, Campus Marburg, Philipps University ...

Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its ...