In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Dead Cells has a lot of weapons, making it perfect for a tier list ranking every weapon. Throughout the game, you'll come across melee weapons, ranged weapons, traps, turrets, and even grenades, each ...

Cell-cycle activation in quiescent cells is correlated with a change in chromatin structure and requires the activation of the retinoblastoma (RB)–E2F pathway. The gain of a new cell fate is ...

Hyperactivation of the Wnt pathway is common in patients with colorectal cancer (CRC), and plays a central role in promoting cancer stem cell renewal and cell proliferation. Therapeutic inhibition of ...

Their collaboration has resulted in engineered cells called ‘synthetic organizers’ that deliver instructions to stem cells, telling them to grow into specific tissues and organs.

These regulators are known as MYB, HDAC2, and FOXA2 and when they were suppressed in colon cancer cells, the cells switched back to a normal-like state, removing the cancer threat without ...

Professor Kwang-Hyun Cho remarked, "The fact that cancer cells can be converted back to normal cells is an astonishing phenomenon. This study proves that such reversion can be systematically induced." ...

We detected an impaired proliferation of WB-affected MuSCs, revealing critical insights into the dysfunctional state of these cells in myopathy. Additionally, by treating MuSCs with blocking peptides ...

A large-scale single-cell study shows aging happens in specific stages driven by molecular cues, offering targets to modify the aging process and revealing key age and sex-related cellular differences ...

The interplay between tumor cells and interstitial cells is pivotal for the progression of tumors, and our previous study indicated that macrophages can support the survival and regulate the ...